Synthesis of Acid Chlorides

You may use these summaries and problems but you may NOT download them for use at another site, nor may you charge for access to them. Copyright Linda M. Sweeting 1997

The following example reactions are organized by type, with references to text chapters. Links within these summaries (which may show up as boxes around reagents) will provide further information about the reagents and their other reactions. Return to Reaction Summary menu for other functional group choices or to reactions of acid chlorides.

Anhydrides are made several different ways. Symmetrical ones are made by dehydration of the carboxylic acid, usually with some inorganic anhydride like P₂O₅ whereas unsymmetrical ones are usually made from acid chlorides

+ SO₂ + HCl
Other reagents: PCl₃ (not as easy to use)
McMurry 21.3, Fessenden 15.3B, Schmid 16.5

Last update February 1999